Document Detail


Congenital diencephalic and brain stem damage: neuropathologic study of three cases.
MedLine Citation:
PMID:  7201224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuropathologic findings and clinical features of three patients with congenital brain stem damage are reported. All of the infants were premature (32 - 36 weeks' gestation) and experienced respiratory difficulty in the immediate postnatal period. One infant was moribund at deliver, dying 3 h after birth. In two infants who survived for 12 and 16 days, detailed neurologic examinations demonstrated multiple cranial nerve palsies with absence of facial expression. Autopsies revealed similar changes in the brains of all three infants: bilateral symmetrical lesions were found predominantly in the thalamus and brain stem. Histological features common to all three cases included prominent basophilic mineralized neurons, neuronal loss astrocytosis and axonal spheroids. Necrosis was observed in two cases. These changes are most compatible with one or more episodes of total asphyxia during fetal life. This study supports the hypothesis that, in some cases, Möbius' syndrome is the result of intrauterine asphyxia.
Authors:
E R Wilson; S S Mirra; J F Schwartz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta neuropathologica     Volume:  57     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1982  
Date Detail:
Created Date:  1982-08-07     Completed Date:  1982-08-07     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  70-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Autopsy
Brain Diseases / congenital*,  etiology,  pathology
Brain Stem / pathology*
Diencephalon / pathology*
Female
Fetal Hypoxia / complications
Humans
Infant, Newborn
Infant, Premature
Male
Necrosis
Pregnancy
Syndrome
Thalamus / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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