| Congenital diaphragmatic hernia. | |
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MedLine Citation:
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PMID: 20610190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Congenital diaphragmatic hernia (CDH) is a congenital anomaly consisting of a posterolateral defect in the diaphragm also known as a Bochdalek hernia. It occurs in 1 in 2000 to 3000 newborns and is associated with a variable degree of pulmonary hypoplasia (PH) and persistent pulmonary hypertension (PPH). Despite remarkable advances in neonatal resuscitation and intensive care and the new postnatal treatment strategies, many newborns with CDH continue to have high rates of mortality and morbidity as the result of severe respiratory failure secondary to PH and PPH. The pathogenesis of CDH and associated PH and PPH is poorly understood. Herein, we aim to review diaphragm and pulmonary development and correlate this to the abnormalities found in CDH. |
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Authors:
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Richard Keijzer; Prem Puri |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Seminars in pediatric surgery Volume: 19 ISSN: 1532-9453 ISO Abbreviation: Semin. Pediatr. Surg. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9216162 Medline TA: Semin Pediatr Surg Country: United States |
Other Details:
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Languages: eng Pagination: 180-5 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatric Surgery, Erasmusmc-Sophia, Rotterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Fundoplication / methods Hernia, Diaphragmatic / complications*, congenital*, surgery Humans Hypertension, Pulmonary / epidemiology, etiology, physiopathology Infant, Newborn Lung / abnormalities*, embryology Lung Diseases / etiology, pathology*, physiopathology Male Prognosis Risk Assessment Severity of Illness Index Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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