Document Detail


Congenital diaphragmatic hernia.
MedLine Citation:
PMID:  20610190     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Congenital diaphragmatic hernia (CDH) is a congenital anomaly consisting of a posterolateral defect in the diaphragm also known as a Bochdalek hernia. It occurs in 1 in 2000 to 3000 newborns and is associated with a variable degree of pulmonary hypoplasia (PH) and persistent pulmonary hypertension (PPH). Despite remarkable advances in neonatal resuscitation and intensive care and the new postnatal treatment strategies, many newborns with CDH continue to have high rates of mortality and morbidity as the result of severe respiratory failure secondary to PH and PPH. The pathogenesis of CDH and associated PH and PPH is poorly understood. Herein, we aim to review diaphragm and pulmonary development and correlate this to the abnormalities found in CDH.
Authors:
Richard Keijzer; Prem Puri
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in pediatric surgery     Volume:  19     ISSN:  1532-9453     ISO Abbreviation:  Semin. Pediatr. Surg.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216162     Medline TA:  Semin Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  180-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pediatric Surgery, Erasmusmc-Sophia, Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Female
Fundoplication / methods
Hernia, Diaphragmatic / complications*,  congenital*,  surgery
Humans
Hypertension, Pulmonary / epidemiology,  etiology,  physiopathology
Infant, Newborn
Lung / abnormalities*,  embryology
Lung Diseases / etiology,  pathology*,  physiopathology
Male
Prognosis
Risk Assessment
Severity of Illness Index
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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