| Congenital diaphragmatic hernia repair during whole body hypothermia for neonatal hypoxic ischemic encephalopathy. | |
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MedLine Citation:
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PMID: 23190939 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Major malformations, surgery and persistent pulmonary hypertension (PHT) have been considered contraindications to therapeutic hypothermia (TH) in newborns with hypoxic-ischemic encephalopathy (HIE). We report two patients with undiagnosed congenital diaphragmatic hernia (CDH) who developed HIE after birth. Diagnosis of moderate HIE was formulated based on clinical, laboratory and electroencephalographic criteria. The patients were treated with whole body hypothermia (33.5 °C) for 72 h. During hypothermia the patients underwent surgical repair with regular perioperative course. Ventilatory support with high-frequency oscillatory ventilation, oxygen requirements and inotropic support remained stable during hypothermia. Serial echocardiographic evaluations did not demonstrate any change in pulmonary pressure values. In our experience TH did not increase the risk of hemodynamic instability, PHT or bleeding. Hypothermia may be considered in patients with HIE and CDH or other surgical conditions with favorable prognosis. |
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Authors:
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S Buratti; E Lampugnani; P Tuo; A Moscatelli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 32 ISSN: 1476-5543 ISO Abbreviation: J Perinatol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 981-4 Citation Subset: IM |
Affiliation:
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Department of Neonatal and Pediatric Anesthesia and Intensive Care, Istituto G. Gaslini, Genova, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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