| Congenital diaphragmatic hernia: lung-to-head ratio and lung volume for prediction of outcome. | |
| | |
MedLine Citation:
|
PMID: 21529758 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of this study was to evaluate observed/expected (O/E) lung-to-head ratio (LHR) by ultrasound (US) and total fetal lung volume (TFLV) by magnetic resonance imaging as neonatal outcome predictors in isolated fetal congenital diaphragmatic hernia (CDH). STUDY DESIGN: We conducted a retrospective study of 72 fetuses with isolated CDH, in whom O/E LHR and TFLV were evaluated as survival predictors. RESULTS: O/E LHR on US and O/E TFLV by magnetic resonance imaging were significantly lower in newborn infants with isolated CDH who died compared with survivors (30.3 ± 8.3 vs 44.2 ± 14.2; P < .0001 for O/E LHR; 21.9 ± 6.3 vs 41.5 ± 17.6; P = .001 for O/E TFLV). Area under receiver-operator characteristics curve for survival for O/E LHR was 0.80 (95% confidence interval, 0.70-0.90). On multivariate analysis, O/E LHR predicted survival, whereas hernia side and first neonatal pH did not. For each unit increase in O/E LHR, mortality odds decreased by 11% (95% confidence interval, 4-17%). CONCLUSION: In fetuses with isolated CDH, O/E LHR (US) independently predicts survival and may predict severity, allowing management to be optimized. |
| | |
Authors:
|
Malikah A Alfaraj; Prakesh S Shah; Desmond Bohn; Sophia Pantazi; Karel O'Brien; Priscilla P Chiu; Rose Gaiteiro; Greg Ryan |
Related Documents
:
|
15490178 - Automated mass detection in contrast-enhanced ct colonography: an approach based on con... 9174028 - Disappearing fetal lung masses: importance of postnatal imaging studies. 1779718 - Mri of female uterine and juxta-uterine masses: clinical application in 25 patients. 9868738 - Imaging findings of some buccomasseteric masses. 15524788 - Observation of feshbach resonances between two different atomic species. 10696018 - Reduced size of the cochlear branch of the vestibulocochlear nerve in a child with sens... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-23 |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: - ISSN: 1097-6868 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
|
Fetal Medicine Unit, Mount Sinai Hospital, Toronto, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Supplementation with vitamins C and E during pregnancy for the prevention of preeclampsia and other ...
Next Document: The relationship between the Trp 64 Arg polymorphism of the beta 3-adrenoceptor gene and idiopathic ...