Document Detail

Congenital diaphragmatic hernia in lambs: hemodynamic and ventilatory changes with breathing.
MedLine Citation:
PMID:  1185447     Owner:  NLM     Status:  MEDLINE    
Left diaphragmatic hernias were produced surgically in ten control lambs at term, and in 19 lambs in 127-144 days' gestation. The hemodynamic and ventilatory changes that occur following delivery and attempted spontaneous breathing were noted. The herniated viscera effectively occluded the diaphragmatic defect, and all lambs were capable of developing negative intrathoracic pressure. Pulmonary artery pressure remained consistently elevated in all lambs with diaphragmatic hernia produced early in gestation. The lambs with diaphragmatic hernia early in gestation had hypoplastic lung with abnormally low air capacity and compliance.
R W Starrett; A A de Lorimier
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  10     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1976-01-29     Completed Date:  1976-01-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  575-82     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Diaphragm / surgery
Hernia, Diaphragmatic / congenital*,  physiopathology
Lung / anatomy & histology
Lung Compliance
Lung Volume Measurements
Organ Size
Oxygen / blood
Pleura / physiopathology
Pulmonary Artery / physiopathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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