Document Detail

Congenital diaphragmatic hernia in an era of delayed repair after medical and/or extracorporeal membrane oxygenation stabilization: a prognostic and management classification.
MedLine Citation:
PMID:  1432527     Owner:  NLM     Status:  MEDLINE    
In November 1987 we began to practice delayed repair of acutely symptomatic congenital diaphragmatic hernia (CDH) following medical and/or extracorporeal membrane oxygenation (ECMO) stabilization. We reviewed 23 consecutive patients with CDH symptomatic at birth treated over the ensuing 2 1/2 years. The mean age at admission, age at repair, and interval from admission to repair were 4.9, 37.0, and 32.6 hours, respectively. Overall survival was 52% (12/23). ECMO was used in 14 patients with 7 survivors (50%); 4 of these patients underwent repair prior to ECMO and 10 while on ECMO. The patients were retrospectively grouped into three classes based on postductal arterial blood gas (ABG) response to conventional medical management: class A (n = 8), able to achieve and sustain adequate oxygenation (PO2 greater than 60 mm Hg) and hyperventilation (PCO2 less than 40 mm Hg); class B (n = 10), unable to sustain adequate oxygenation (PO2 less than 60 mm Hg) but able to be hyperventilated (PCO2 less than 40 mm Hg); and class C (n = 5), unable to be oxygenated (PO2 less than 60 mm Hg) or hyperventilated (PCO2 greater than 40 mm Hg). The interval from admission to repair was 13.6, 53.5, and 25.4 hours for classes A, B, and C, respectively. Two class A (25%), nine class B (90%), and three class C patients (60%) were placed on ECMO. Survival rates were 88%, 50%, and 0% for classes A, B, and C, respectively. We propose the following management protocol. Class A patients are stable and can be repaired at any convenient point after admission without prerepair ECMO; few will need it afterward.(ABSTRACT TRUNCATED AT 250 WORDS)
C W Breaux; T M Rouse; W S Cain; K E Georgeson
Related Documents :
3769387 - Indoramin in heart failure: possible adverse effects on hemodynamics and exercise capac...
8193607 - Mineralocorticoid induced hypertension and noradrenaline spillover in man.
23497457 - The effect of vasopressin on the hemodynamics in cabg patients.
3180397 - Skeletal muscle grafts applied to the heart. a word of caution.
19661927 - Family-based randomized trial to detect effects on blood pressure of a salt substitute ...
23429477 - Localized retinal nerve fiber layer defects and arterial hypertension.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  27     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-12-03     Completed Date:  1992-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1192-6     Citation Subset:  IM    
Department of Surgery, Children's Hospital of Alabama, Birmingham 35233.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Extracorporeal Membrane Oxygenation*
Hernia, Diaphragmatic / classification,  congenital*,  mortality,  therapy*
Infant, Newborn
Survival Rate
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Proximal and distal cannulation of the internal jugular vein for ECMO in a primate.
Next Document:  Major surgical intervention during extracorporeal membrane oxygenation.