Document Detail

Congenital conduction defects in children born to asymptomatic mothers with anti-SSA/SSB antibodies: report of two cases.
MedLine Citation:
PMID:  9859574     Owner:  NLM     Status:  MEDLINE    
It is very difficult to identify pregnant asymptomatic mothers carrying anti-SSA/SSB antibodies. We report two cases of neonatal lupus erythematosus, born to asymptomatic mothers with anti-SSA/Ro antibody, who developed isolated complete congenital cardiac heart block and transient second degree conduction defect associated with cardiac abnormalities, respectively. The first died suddenly of acute myocarditis at the age of 20 months, while the second underwent surgery at the age of 10 years for a ventricular septal defect, after two episodes of second degree atrioventricular block in infancy. We believe that in both cases the diagnosis could have been made in utero after correct heart beat analysis. We propose careful monitoring of fetal heart beat in all pregnant mothers. The occurrence of heart beat modification should prompt clinicians to test the mother for antibody positivity. This approach may permit early diagnosis and in utero treatment in order to spare the child from cardiac conduction defects. We provide the evidence of these cases and propose a flow chart for all physicians dealing with pregnancy.
F Falcini; L De Simone; G Donzelli; M M Cerinic
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annali italiani di medicina interna : organo ufficiale della Società italiana di medicina interna     Volume:  13     ISSN:  0393-9340     ISO Abbreviation:  Ann. Ital. Med. Int.     Publication Date:    1998 Jul-Sep
Date Detail:
Created Date:  1998-12-31     Completed Date:  1998-12-31     Revised Date:  2007-05-11    
Medline Journal Info:
Nlm Unique ID:  8806705     Medline TA:  Ann Ital Med Int     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
Dipartimento di Pediatria, Servizio di Reumatologia, Azienda Ospedaliera A. Meyer di Firenze.
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MeSH Terms
Antibodies / blood*
Autoantigens / immunology*
Heart Block / congenital*,  immunology
Infant, Newborn
Lupus Erythematosus, Systemic / congenital*,  immunology
Prenatal Exposure Delayed Effects
RNA, Small Cytoplasmic*
Ribonucleoproteins / immunology*
Reg. No./Substance:
0/Antibodies; 0/Autoantigens; 0/RNA, Small Cytoplasmic; 0/Ribonucleoproteins; 0/SS-A antigen; 0/SS-B antigen; 0/TROVE2 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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