Document Detail

Congenital complete heart block and SSA antibodies: obstetric implications.
MedLine Citation:
PMID:  3895939     Owner:  NLM     Status:  MEDLINE    
Mothers with known or occult rheumatic disorders may be delivered of infants with congenital complete heart block. The more frequent use of ultrasonography during pregnancy now allows early detection of heart block in utero. The transplacental passage of SSA or SSB antibodies, of the IgG class, may mediate or be associated with immune damage to the fetal cardiac conduction system, as reported in our two patients. Maternal and/or newborn screening for SSA and SSB antibodies in selected patients permits an early presumptive diagnosis and will assist perinatal planning, particularly for immediate newborn cardiac pacemaker implantation. Early serologic detection of such antibodies may also assist family counseling of mothers at risk and should promote investigation of techniques to modify the immune status of these mothers. SSA- or SSB-positive maternal/fetal pairs should be prospectively managed by the obstetrician, neonatologist, and rheumatologist.
B H Singsen; J E Akhter; M M Weinstein; G C Sharp
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  152     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-30     Completed Date:  1985-08-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  655-8     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Antinuclear / analysis,  immunology*
Fetal Diseases / diagnosis
Heart Block / congenital*,  diagnosis,  immunology
Infant, Newborn
Lupus Erythematosus, Systemic / immunology*
Maternal-Fetal Exchange
Pregnancy Complications / immunology*
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/SS-A antibodies; 0/SS-B antibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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