Document Detail

Congenital combined deficiency of coagulation factors VII and II in a young adult.
MedLine Citation:
PMID:  21189713     Owner:  NLM     Status:  In-Process    
We present herein a case of a young female with congenital combined coagulation factor VII (FVII) and factor II (FII) deficiencies. She was completely asymptomatic and found to have a prolonged prothrombin time during a routine preoperative evaluation. Low levels of plasma FVII and FII in the absence of an inhibitor confirmed the diagnosis in our patient. Congenital combined FVII and FIX deficiency as well as combined FVII and FX deficiency have been previously reported. The congenital combined deficiency of FVII and FII in our patient is exceptional and represents the first such instance in the English literature. Furthermore, we hypothesize that she had not shown any bleeding manifestations because of possible compensation for the missing factors II and VII by enhanced activity of some intrinsic coagulation pathway components or depression of fibrinolysis.
Constantin A Dasanu; Frances O Natale; Hema N DeSilva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Connecticut medicine     Volume:  74     ISSN:  0010-6178     ISO Abbreviation:  Conn Med     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-12-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372745     Medline TA:  Conn Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-3     Citation Subset:  IM    
Department of Hematology-Oncology, Saint Francis Hospital and Medical Center, Gothic Park, 43 Woodland Street, Suite G-80, Hartford, CT 06105, USA.
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