| Congenital combined deficiency of coagulation factors VII and II in a young adult. | |
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MedLine Citation:
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PMID: 21189713 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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We present herein a case of a young female with congenital combined coagulation factor VII (FVII) and factor II (FII) deficiencies. She was completely asymptomatic and found to have a prolonged prothrombin time during a routine preoperative evaluation. Low levels of plasma FVII and FII in the absence of an inhibitor confirmed the diagnosis in our patient. Congenital combined FVII and FIX deficiency as well as combined FVII and FX deficiency have been previously reported. The congenital combined deficiency of FVII and FII in our patient is exceptional and represents the first such instance in the English literature. Furthermore, we hypothesize that she had not shown any bleeding manifestations because of possible compensation for the missing factors II and VII by enhanced activity of some intrinsic coagulation pathway components or depression of fibrinolysis. |
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Authors:
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Constantin A Dasanu; Frances O Natale; Hema N DeSilva |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Connecticut medicine Volume: 74 ISSN: 0010-6178 ISO Abbreviation: Conn Med Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372745 Medline TA: Conn Med Country: United States |
Other Details:
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Languages: eng Pagination: 581-3 Citation Subset: IM |
Affiliation:
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Department of Hematology-Oncology, Saint Francis Hospital and Medical Center, Gothic Park, 43 Woodland Street, Suite G-80, Hartford, CT 06105, USA. c_dasanu@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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