| Congenital blindness, porencephaly, and neonatal thrombocytopenia: a report of four cases. | |
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MedLine Citation:
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PMID: 3372970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four unrelated infants with neonatal thrombocytopenia associated with congenital blindness and porencephaly have been seen over an 18-year period. The association of congenital blindness with neonatal thrombocytopenia has not previously been reported. All children had clinical purpura in the neonatal period; in three cases, thrombocytopenia was confirmed, while in one case, the diagnosis of thrombocytopenia was presumptive; in two cases, there was evidence of circulating maternal serum platelet isoantibodies. Extensive investigation for intrauterine infection was negative in the three cases with confirmed thrombocytopenia. The thrombocytopenia resolved spontaneously after the neonatal period. It is postulated that the porencephalies were the consequence of prenatal cerebrovascular episodes. The etiology of the optic atrophy is unclear. Serial cranial ultrasound investigation is recommended for all neonates with thrombocytopenia, even if neurologically asymptomatic in the neonatal period, and serial prenatal cranial ultrasound investigation is recommended for infants of mothers with a history of having previously had infants with neonatal isoimmune thrombocytopenia. |
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Authors:
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J Manson; I Speed; K Abbott; J Crompton |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of child neurology Volume: 3 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-07-12 Completed Date: 1988-07-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 120-4 Citation Subset: IM |
Affiliation:
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Department of Neurology, Adelaide Children's Hospital, North Adelaide, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Blindness / complications, congenital* Brain / abnormalities*, radiography Child Eye Movements Female Humans Infant Infant, Newborn Male Thrombocytopenia / complications* Tomography, X-Ray Computed |
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