Document Detail


Congenital blindness, porencephaly, and neonatal thrombocytopenia: a report of four cases.
MedLine Citation:
PMID:  3372970     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four unrelated infants with neonatal thrombocytopenia associated with congenital blindness and porencephaly have been seen over an 18-year period. The association of congenital blindness with neonatal thrombocytopenia has not previously been reported. All children had clinical purpura in the neonatal period; in three cases, thrombocytopenia was confirmed, while in one case, the diagnosis of thrombocytopenia was presumptive; in two cases, there was evidence of circulating maternal serum platelet isoantibodies. Extensive investigation for intrauterine infection was negative in the three cases with confirmed thrombocytopenia. The thrombocytopenia resolved spontaneously after the neonatal period. It is postulated that the porencephalies were the consequence of prenatal cerebrovascular episodes. The etiology of the optic atrophy is unclear. Serial cranial ultrasound investigation is recommended for all neonates with thrombocytopenia, even if neurologically asymptomatic in the neonatal period, and serial prenatal cranial ultrasound investigation is recommended for infants of mothers with a history of having previously had infants with neonatal isoimmune thrombocytopenia.
Authors:
J Manson; I Speed; K Abbott; J Crompton
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of child neurology     Volume:  3     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-07-12     Completed Date:  1988-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  120-4     Citation Subset:  IM    
Affiliation:
Department of Neurology, Adelaide Children's Hospital, North Adelaide, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Blindness / complications,  congenital*
Brain / abnormalities*,  radiography
Child
Eye Movements
Female
Humans
Infant
Infant, Newborn
Male
Thrombocytopenia / complications*
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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