Document Detail

Congenital aortic valve disease with rupture of mitral chordae tendineae.
MedLine Citation:
PMID:  973889     Owner:  NLM     Status:  MEDLINE    
A new clinical entity is described in which free aortic regurgitation from congenital aortic valve disease caused rupture of the chordae to the anterior leaflet of the mitral valve in 7 men aged 45 to 63 years (mean 52 years); 2 of the patients also had rupture of chordae to the posterior leaflet. Comparing these patients with those with ruptured mitral chordae in association with rheumatic heart disease and patients with spontaneous chordal rupture, differences were evident. No patient had a history of rheumatic fever and none had active infection. The typical clinical presentation was of acute mitral regurgitation into a small left atrium, with severe pulmonary oedema which was often resistant to medical treatment. The cause of chordal rupture in these patients was in part the result of progressive left ventricular dilatation, of direct trauma to the anterior cusp of the mitral valve, and possibly of a genetic factor. The anatomical features of both aortic and mitral valves are described, and in 3 histology of the mitral valve was available; 2 had myxomatous degeneration similar to that seen in patients with spontaneous chordal rupture, and in 1 there was degeneration of collagen tissue. All patients were treated surgically but the mortality was high (5 out of 7,70%). Early operation with replacement of the aortic and mitral valves is recommended if this high mortality is to be reduced.
S Joseph; R Emanuel; M Sturridge; E Olsen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  38     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  665-73     Citation Subset:  AIM; IM    
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MeSH Terms
Aortic Valve / pathology
Aortic Valve Insufficiency / congenital*,  pathology
Chordae Tendineae*
Middle Aged
Mitral Valve / pathology
Mitral Valve Insufficiency* / etiology*
Rupture, Spontaneous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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