Document Detail

Congenital aortic valve disease with rupture of mitral chordae tendineae.
MedLine Citation:
PMID:  973889     Owner:  NLM     Status:  MEDLINE    
A new clinical entity is described in which free aortic regurgitation from congenital aortic valve disease caused rupture of the chordae to the anterior leaflet of the mitral valve in 7 men aged 45 to 63 years (mean 52 years); 2 of the patients also had rupture of chordae to the posterior leaflet. Comparing these patients with those with ruptured mitral chordae in association with rheumatic heart disease and patients with spontaneous chordal rupture, differences were evident. No patient had a history of rheumatic fever and none had active infection. The typical clinical presentation was of acute mitral regurgitation into a small left atrium, with severe pulmonary oedema which was often resistant to medical treatment. The cause of chordal rupture in these patients was in part the result of progressive left ventricular dilatation, of direct trauma to the anterior cusp of the mitral valve, and possibly of a genetic factor. The anatomical features of both aortic and mitral valves are described, and in 3 histology of the mitral valve was available; 2 had myxomatous degeneration similar to that seen in patients with spontaneous chordal rupture, and in 1 there was degeneration of collagen tissue. All patients were treated surgically but the mortality was high (5 out of 7,70%). Early operation with replacement of the aortic and mitral valves is recommended if this high mortality is to be reduced.
S Joseph; R Emanuel; M Sturridge; E Olsen
Related Documents :
21362339 - Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming ...
11137809 - Is posterior leaflet preservation in the surgical treatment of rheumatic mitral insuffi...
9486259 - Mitral valve opening in the ovine heart.
15227509 - Embolizing papillary fibroelastoma of the mitral valve.
21150449 - Fibrosis and cardiac arrhythmias.
15651409 - Left ventricular rupture following mitral valve replacement due to oversize prosthesis.
20486829 - Growth hormone and testosterone in heart failure therapy.
12796769 - Prospective evaluation comparing the effects of enalapril and losartan in left ventricu...
10955369 - Assessment of coagulation and platelet activation in coronary sinus blood induced by tr...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  38     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  665-73     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aortic Valve / pathology
Aortic Valve Insufficiency / congenital*,  pathology
Chordae Tendineae*
Middle Aged
Mitral Valve / pathology
Mitral Valve Insufficiency* / etiology*
Rupture, Spontaneous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pathology of acute myocardial infarction with particular reference to occlusive coronary thrombi.
Next Document:  Endocardial cushion defects: an anatomical study of 54 specimens.