| Congenital anosmia. | |
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MedLine Citation:
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PMID: 2379478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven patients with congenital anosmia underwent detailed chemosensory evaluation, followed by the performance of biopsies of the olfactory region. Olfactory epithelium was not found in any of the biopsy specimens. It appears therefore that patients with congenital anosmia lack any olfactory epithelium. Several possible explanations for this finding are discussed. The most attractive hypothesis is that the olfactory placode forms either normally or abnormally during development but later degenerates and is replaced with respiratory epithelium. Only one patient in our series had congenital anosmia in association with a syndrome (Kallmann's syndrome), indicating that congenital anosmia is found more often as an isolated symptom. |
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Authors:
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B W Jafek; A S Gordon; D T Moran; P M Eller |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Ear, nose, & throat journal Volume: 69 ISSN: 0145-5613 ISO Abbreviation: Ear Nose Throat J Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-09-07 Completed Date: 1990-09-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7701817 Medline TA: Ear Nose Throat J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 331-7 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Head and Neck Surgery, University of Colorado School of Medicine, Denver. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biopsy Eunuchism / complications Female Humans Male Middle Aged Olfaction Disorders / congenital*, embryology, pathology Olfactory Mucosa / embryology, pathology* Sensory Thresholds / physiology Smell / physiology Taste / physiology |
| Grant Support | |
ID/Acronym/Agency:
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2 PO1 DC 00244/DC/NIDCD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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