Document Detail

Congenital anomalies of soft tissues: birth defects depending on tissue engineering solutions and present advances in regenerative medicine.
MedLine Citation:
PMID:  20196647     Owner:  NLM     Status:  MEDLINE    
Congenital anomalies encompass a wide range of malformations that could affect various organs and tissues in the newborn and infant population. These disorders that involve defects in or injury to a developing fetus may be a result of genetic abnormalities or mutations, alterations in the intrauterine environment, irregularities in morphogenesis, or chromosomal aberration. The outcome of these defects could lead to minor anomalies or major malformations that are dependent on the complex processes between the prenatal deficit and postnatal environment. Often multiple malformations occur within the same fetus and give rise to a malformation syndrome. Since congenital anomalies are evident at birth, solutions must be found to improve the clinical state and quality of life that a newborn has to lead from infancy through adolescence into adulthood. Transplantation options in this age group are limited due to the shortage of organs and the discrepancy in adult donor size mismatch. Over the past 2 decades tremendous strides have been made in the research of biomaterials, stem cells, organ generation, and tissue engineering to provide viable solutions to a wide range of organ and tissue losses focusing on the adult population. This review intends to highlight the shortage of tissue and organs in neonates and infants with congenital malformations. This is also the first monograph that presents estimation of incidences of the congenital malformations based on an extensive literature search. It also outlines the challenges in clinical management of these entities and presents an organ-based demand for engineered tissues.
Amulya K Saxena
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Tissue engineering. Part B, Reviews     Volume:  16     ISSN:  1937-3376     ISO Abbreviation:  Tissue Eng Part B Rev     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466660     Medline TA:  Tissue Eng Part B Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  455-66     Citation Subset:  IM    
Department of Pediatric and Adolescent Surgery, Medical University of Graz, Graz, Austria.
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MeSH Terms
Abnormalities, Multiple*
Congenital Abnormalities*
Regenerative Medicine / trends*
Tissue Donors / supply & distribution
Tissue Engineering / methods*

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