Document Detail

Congenital anomalies in infants conceived by assisted reproductive techniques.
MedLine Citation:
PMID:  22424041     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Many studies show that congenital defects in infants conceived by assisted reproductive techniques (ART) are more than infants of normal conception (NC). The aim of this study is to determine the frequency of congenital anomalies in ART infants from Royan Institute and to compare congenital anomalies between two ART techniques. 
METHODS: In a cross-sectional descriptive study, 400 ART infants from Royan Institute who resided in Tehran were selected by non-random, consecutive sampling. Infants were examined twice (until 9 months of age) by a pediatrician. Infants' congenital anomalies were described by each body system or organ and type of ART. Data were analyzed by SPSS version 16 and Fisher's exact test.
RESULTS: The frequency of different organ involvement in the two examinations were: 40 (10%) skin, 25 (6.2%) urogenital system, 21 (5.2%) gastrointestinal tract, 13 (3.2%) visual, and 8 (2%) cardiovascular system. Major congenital defects in infants conceived by in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) were hypospadiasis, inguinal hernia, patent ductus arteriosus plus ventricular septal defect (PDA + VSD), developmental dysplasia of the hip, lacrimal duct stenosis during the first year of life, hydronephrosis and urinary reflux over grade III, undescending testis, ureteropelvic junction stenosis, and torticoli.
CONCLUSIONS: Two-thirds of ART infants had no defects. A total of 7% of IVF and ICSI infants had one of the major abovementioned congenital anomalies. This rate was higher than NC infants (2%-3%). There was no difference between the ICSI and IVF group.
Ramin Mozafari Kermani; Leila Nedaeifard; Mohammad Reza Nateghi; Abolhassan Shahzadeh Fazeli; Ebrahim Ahmadi; Mohammad Ali Osia; Ebrahim Jafarzadehpour; Soudabeh Nouri
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of Iranian medicine     Volume:  15     ISSN:  1735-3947     ISO Abbreviation:  Arch Iran Med     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-19     Completed Date:  2012-06-13     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  100889644     Medline TA:  Arch Iran Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  228-31     Citation Subset:  IM    
Child Health and Development Research Department, Tehran Medical Sciences, Branch of Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.
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MeSH Terms
Congenital Abnormalities / epidemiology*,  etiology
Cross-Sectional Studies
Cryptorchidism / epidemiology
Ductus Arteriosus, Patent / epidemiology
Fertilization in Vitro / adverse effects*,  statistics & numerical data*
Heart Septal Defects, Ventricular / epidemiology
Hernia, Inguinal / congenital,  epidemiology
Hip / abnormalities
Hydronephrosis / congenital,  epidemiology
Hypospadias / epidemiology
Infant, Newborn
Iran / epidemiology
Lacrimal Apparatus / abnormalities
Sperm Injections, Intracytoplasmic / adverse effects,  statistics & numerical data
Torticollis / congenital,  epidemiology
Ureter / abnormalities

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