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Congenital anomalies in infant with congenital hypothyroidism.
MedLine Citation:
PMID:  23074545     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: Congenital hypothyroidism is characterized by inadequate thyroid hormone production in newborn infants. Many infants with CH have co-occurring congenital malformations. This is an investigation on the frequency and types of congenital anomalies in infants with congenital hypothyroidism born from May 2006-2010 in Hamadan, west province of Iran.
METHODS: The Iranian neonatal screening program for congenital hypothyroidism was initiated in May 2005. This prospective descriptive study was conducted in infants diagnosed with congenital hypothyroidism being followed up in Pediatric Endocrinology Clinic of Besat Hospital, a tertiary care centre in Hamadan. Cases included all infants with congenital hypothyroidism diagnosed through newborn screening program or detected clinically. Anomalies were identified by clinical examination, echocardiography, and X-ray of the hip during the infant's first year of life.
RESULTS: A total of 150 infants with biochemically confirmed primary congenital hypothyroidism (72 females and 78 males) were recruited during the period between May 2006-2010. Overall, 30 (20%) infants had associated congenital anomalies. The most common type of anomaly was Down syndrome. Seven infants (3.1%) had congenital cardiac anomalies such as: ASD (n=3), VSD (n=2), PS (n =1), PDA (n=1). Three children (2.6%) had developmental dysplasia of the hip (n=3).
CONCLUSION: The overall frequency of Down syndrome, cardiac malformation and other birth defect was high in infants with CH. This reinforces the need to examine all infants with congenital hypothyroidism for the presence of associated congenital anomalies.
Zahra Razavi; Alireza Yavarikia; Saadat Torabian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oman medical journal     Volume:  27     ISSN:  2070-5204     ISO Abbreviation:  Oman Med J     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-17     Completed Date:  2012-10-18     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101526350     Medline TA:  Oman Med J     Country:  Oman    
Other Details:
Languages:  eng     Pagination:  364-7     Citation Subset:  -    
Associate Professor, Pediatric Endocrinologist, Pediatrics Department, Faculty of Medicine, Hamedan University of Medical Sciences.
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