| Congenital anomalies in infant with congenital hypothyroidism. | |
| | |
MedLine Citation:
|
PMID: 23074545 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Congenital hypothyroidism is characterized by inadequate thyroid hormone production in newborn infants. Many infants with CH have co-occurring congenital malformations. This is an investigation on the frequency and types of congenital anomalies in infants with congenital hypothyroidism born from May 2006-2010 in Hamadan, west province of Iran. METHODS: The Iranian neonatal screening program for congenital hypothyroidism was initiated in May 2005. This prospective descriptive study was conducted in infants diagnosed with congenital hypothyroidism being followed up in Pediatric Endocrinology Clinic of Besat Hospital, a tertiary care centre in Hamadan. Cases included all infants with congenital hypothyroidism diagnosed through newborn screening program or detected clinically. Anomalies were identified by clinical examination, echocardiography, and X-ray of the hip during the infant's first year of life. RESULTS: A total of 150 infants with biochemically confirmed primary congenital hypothyroidism (72 females and 78 males) were recruited during the period between May 2006-2010. Overall, 30 (20%) infants had associated congenital anomalies. The most common type of anomaly was Down syndrome. Seven infants (3.1%) had congenital cardiac anomalies such as: ASD (n=3), VSD (n=2), PS (n =1), PDA (n=1). Three children (2.6%) had developmental dysplasia of the hip (n=3). CONCLUSION: The overall frequency of Down syndrome, cardiac malformation and other birth defect was high in infants with CH. This reinforces the need to examine all infants with congenital hypothyroidism for the presence of associated congenital anomalies. |
| | |
Authors:
|
Zahra Razavi; Alireza Yavarikia; Saadat Torabian |
Related Documents
:
|
15023375 - Neonatal seizures and limb malformations associated with liver-specific complex iv resp... 10406025 - Antisense oligonucleotides to c-fos reduce postictal seizure susceptibility following f... 7824225 - Term early-onset neonatal seizures: obstetric characteristics, etiologic classification... 22991775 - Risk factors associated with retinopathy of prematurity and visual alterations in infan... 3606755 - Thoracic spinal cord (t3-t4) transection in a breech-presenting, cesarean-section-deliv... 19382955 - Assessment and predictor determination of indoor aldehyde levels in paris newborn babie... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Oman medical journal Volume: 27 ISSN: 2070-5204 ISO Abbreviation: Oman Med J Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-10-17 Completed Date: 2012-10-18 Revised Date: 2013-04-02 |
Medline Journal Info:
|
Nlm Unique ID: 101526350 Medline TA: Oman Med J Country: Oman |
Other Details:
|
Languages: eng Pagination: 364-7 Citation Subset: - |
Affiliation:
|
Associate Professor, Pediatric Endocrinologist, Pediatrics Department, Faculty of Medicine, Hamedan University of Medical Sciences. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Five-year Review on the Etiology and Antimicrobial Susceptibility Pattern of Otitis Media Pathogen...
Next Document: Immunohistochemical Expression of Ki-67, PCNA and CD34 in Astrocytomas: A Clinicopathological Study.