Document Detail


Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms.
MedLine Citation:
PMID:  175914     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifty-eight women who conceived following successful chemotherapy of gestational trophoblastic neoplasms subsequently became pregnant a total of 96 times. Seventy-eight of these 96 pregnancies or 81% terminated in live-born infants. Fifteen of the 96 or 16% ended in abortion and three or 3% terminated with stillborn infants. Among the live-born and stillborn infants there were three with congenital malformations classified as major. While this incidence of congenital malformations does not appear to be increased over that expected, the numbers are too small to perceive a two-fold increase in the expected incidence. Suggestions are made for improvements in the quality of these data.
Authors:
G T Ross
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  37     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-06-02     Completed Date:  1976-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1043-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology*
Antineoplastic Agents / adverse effects*
Chlorambucil / therapeutic use
Drug Therapy, Combination
Female
Humans
Mechlorethamine / therapeutic use
Methotrexate / therapeutic use
Placenta Accreta / epidemiology
Pregnancy
Pregnancy Complications
Trophoblastic Neoplasms / drug therapy*
Uterine Neoplasms / drug therapy*
Vinblastine / therapeutic use
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 305-03-3/Chlorambucil; 51-75-2/Mechlorethamine; 59-05-2/Methotrexate; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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