| Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms. | |
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MedLine Citation:
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PMID: 175914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty-eight women who conceived following successful chemotherapy of gestational trophoblastic neoplasms subsequently became pregnant a total of 96 times. Seventy-eight of these 96 pregnancies or 81% terminated in live-born infants. Fifteen of the 96 or 16% ended in abortion and three or 3% terminated with stillborn infants. Among the live-born and stillborn infants there were three with congenital malformations classified as major. While this incidence of congenital malformations does not appear to be increased over that expected, the numbers are too small to perceive a two-fold increase in the expected incidence. Suggestions are made for improvements in the quality of these data. |
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Authors:
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G T Ross |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer Volume: 37 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1976 Feb |
Date Detail:
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Created Date: 1976-06-02 Completed Date: 1976-06-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1043-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology* Antineoplastic Agents / adverse effects* Chlorambucil / therapeutic use Drug Therapy, Combination Female Humans Mechlorethamine / therapeutic use Methotrexate / therapeutic use Placenta Accreta / epidemiology Pregnancy Pregnancy Complications Trophoblastic Neoplasms / drug therapy* Uterine Neoplasms / drug therapy* Vinblastine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 305-03-3/Chlorambucil; 51-75-2/Mechlorethamine; 59-05-2/Methotrexate; 865-21-4/Vinblastine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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