Document Detail


Congenital adrenal hyperplasia and luteal dysfunction.
MedLine Citation:
PMID:  2868937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of 21-hydroxylase deficiency diagnosed and first treated at the age of 3 years is presented. Although pubertal development was delayed, full reproductive function was attained, with menses occurring at 14-33-day intervals. Infertility evaluation at age 20 revealed elevated 17-hydroxyprogesterone (17Po) and androgen concentrations and reduced luteal phase progesterone levels consistent with inadequate luteal function. This was corrected with additional corticosteroid replacement. Normal pregnancy and delivery followed.
Authors:
A L Villanueva; R W Rebar
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  23     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-03-28     Completed Date:  1986-03-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  449-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
17-alpha-Hydroxyprogesterone
Adrenal Hyperplasia, Congenital* / complications,  drug therapy,  physiopathology*
Adult
Androgens / blood
Female
Humans
Hydrocortisone / therapeutic use
Hydroxyprogesterones / blood
Infertility, Female / etiology
Luteal Phase*
Pregnancy
Steroid Hydroxylases / deficiency*
Grant Support
ID/Acronym/Agency:
HD-12303/HD/NICHD NIH HHS; HD-19542/HD/NICHD NIH HHS; RR-00827/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Androgens; 0/Hydroxyprogesterones; 50-23-7/Hydrocortisone; 68-96-2/17-alpha-Hydroxyprogesterone; EC 1.14.-/Steroid Hydroxylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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