Document Detail


Congenital acute lymphoblastic leukemia: a two-case report and a review of the literature.
MedLine Citation:
PMID:  21046414     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Congenital leukemia is a rare disease with particular biological and clinical characteristics which differs from those of older children and adults. Here, we describe two cases of congenital acute lymphoblastic leukemia in two newborns with different clinical presentations (leukemia cutis vs. splenomegaly and respiratory distress) and fatal outcome. Both cases shared the expression of myeloid antigens (CD65) and cytogenetic disorders involving the MLL gene (location 11q23) which are associated to extremely poor prognosis.
Authors:
Ma Pilar Bas Suárez; Jezabel López Brito; Candelaria Santana Reyes; Manuel Gresa Muñoz; Rosario Diaz Pulido; Jose Carlos Lodos Rojas
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Publication Detail:
Type:  Journal Article     Date:  2010-11-03
Journal Detail:
Title:  European journal of pediatrics     Volume:  170     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  531-4     Citation Subset:  IM    
Affiliation:
Department of Neonatology, University Hospital Maternity Ward of the Canary Islands, Las Palmas, Spain, pilybas@yahoo.es.
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