Document Detail

Congenital Langerhans Cell Histiocytosis with Placental Involvement.
MedLine Citation:
PMID:  23432454     Owner:  NLM     Status:  Publisher    
Abstract Congenital presentations of Langerhans cell histiocytosis (LCH) are exceedingly rare and concurrent placental parenchymal involvement has not been definitively documented in the literature. We present two cases of congenital MS-LCH with placental involvement resembling chronic villitis. Placental examination may provide the initial diagnostic evidence of LCH and may significantly influence patient management and outcome; however, the prognostic implications remain unclear. In a clinical context suspicious for congenital LCH, the observation of chronic villitis should prompt consideration of placental involvement by LCH.
Jefferson Terry; Francesca Pluchinotta; Stephen Sanders; Jo-Anne Vergilio; Scott Hyde; Theonia K Boyd
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-22
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a McMaster Children's Hospital, Pathology and Molecular Medicine.
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