| Congenital Hypothyroidism with a Delayed Thyroid-Stimulating Hormone Elevation in Very Premature Infants: Incidence and Growth and Developmental Outcomes. | |
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MedLine Citation:
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PMID: 21232766 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To test the hypothesis that very low birth weight (VLBW) and extremely low birth weight (ELBW) infants have an increased incidence of congenital hypothyroidism (CH) with a delayed thyroid-stimulating hormone (TSH) elevation and that the outcomes of these infants are similar to control infants. STUDY DESIGN: Retrospective analysis of newborn thyroid screening data for 92 800 live births in Rhode Island to identify CH with a delayed TSH elevation. Developmental, growth, and endocrine outcomes of the index cases were assessed at 18 months corrected age. RESULTS: CH with a delayed TSH elevation occurred in 1 in 58 ELBW, 1 in 95 VLBW, and 1 in 30 329 infants weighing ≥1500 grams (P < .0001). The incidence of head circumference <10(th) percentile was higher in VLBW infants with CH associated with a delayed TSH elevation (P < .05), and the mean head circumferences, weights, lengths, and developmental scores were similar to matched control infants. Three infants received short-term levothyroxine replacement. CONCLUSIONS: The incidence of CH with a delayed TSH elevation was higher in ELBW and VLBW infants compared with infants weighing ≥1500 grams. The outcomes of these infants were comparable with matched control infants. |
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Authors:
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Hyung Chul Woo; Ariel Lizarda; Richard Tucker; Marvin L Mitchell; Betty Vohr; William Oh; Chanika Phornphutkul |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-11 |
Journal Detail:
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Title: The Journal of pediatrics Volume: - ISSN: 1097-6833 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, RI. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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