Document Detail


Congenital heart disease affects cerebral size but not brain growth.
MedLine Citation:
PMID:  22450354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infants with congenital heart disease (CHD) have delayed brain maturation and alterations in brain volume. Brain metrics is a simple measurement technique that can be used to evaluate brain growth. This study used brain metrics to test the hypothesis that alterations in brain size persist at 3 months of age and that infants with CHD have slower rates of brain growth than control infants. Fifty-seven infants with CHD underwent serial brain magnetic resonance imaging (MRI). To evaluate brain growth across the first 3 months of life, brain metrics were undertaken using 19 tissue and fluid spaces shown on MRIs performed before surgery and again at 3 months of age. Before surgery, infants with CHD have smaller frontal, parietal, cerebellar, and brain stem measures (p < 0.001). At 3 months of age, alterations persisted in all measures except the cerebellum. There was no difference between control and CHD infants in brain growth. However, the cerebellum trended toward greater growth in infants with CHD. Somatic growth was the primary factor that related to brain growth. Presence of focal white matter lesions before and after surgery did not relate to alterations in brain size or growth. Although infants with CHD have persistent alterations in brain size at 3 months of age, rates of brain growth are similar to that of healthy term infants. Somatic growth was the primary predictor of brain growth, emphasizing the importance of optimal weight gain in this population.
Authors:
Cynthia Ortinau; Terrie Inder; Jennifer Lambeth; Michael Wallendorf; Kirsten Finucane; John Beca
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-03-27
Journal Detail:
Title:  Pediatric cardiology     Volume:  33     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-14     Completed Date:  2013-02-12     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1138-46     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, St. Louis Children's Hospital, Washington University in St. Louis, St. Louis, MO 63110, USA. ortinau_c@kids.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Brain / growth & development*,  pathology*
Case-Control Studies
Chi-Square Distribution
Female
Heart Defects, Congenital / pathology*
Humans
Infant
Longitudinal Studies
Magnetic Resonance Imaging
Male
Prospective Studies
Regression Analysis
Grant Support
ID/Acronym/Agency:
P30 HD062171/HD/NICHD NIH HHS; P30HD062171/HD/NICHD NIH HHS; T32 HD043010/HD/NICHD NIH HHS; T32 HD043010/HD/NICHD NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1RR024992/RR/NCRR NIH HHS
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