Document Detail


Congenital Chagas disease: diagnostic and clinical aspects in an area without vectorial transmission, Bermejo, Bolivia.
MedLine Citation:
PMID:  18448076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors carried out a 1-year study of a population of pregnant women delivering at Bermejo hospital, South Bolivia. In this area, vectorial transmission of Trypanosoma cruzi is negligible and women infect themselves during displacements in close endemic areas. The prevalence of T. cruzi in 508 pregnant women, diagnosed by several serological tests, was 33.9%. In eight infants, we observed T. cruzi in the umbilical cord (congenital transmission rate of 5.2%). The means of birth weights, lengths and hemoglobin rates were similar in the children from both seronegative and seropositive women, and in children infected or not by T. cruzi. This study could confirm a less severity of the congenital disease of Chagas in the absence of re-infestation of the mother during pregnancy. Serological screening of pregnant women by rapid diagnostic tests and examination of babies born from seropositive mothers by microhematocrit method at birth is a suitable strategy to detect and prevent congenital Chagas disease in non-endemic areas.
Authors:
L Brutus; D Schneider; J Postigo; M Romero; J Santalla; J P Chippaux
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-27
Journal Detail:
Title:  Acta tropica     Volume:  106     ISSN:  0001-706X     ISO Abbreviation:  Acta Trop.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-26     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370374     Medline TA:  Acta Trop     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  195-9     Citation Subset:  IM    
Affiliation:
IRD UR010, Research Unit Mother's and Child's Health in Tropical Environment, Institut de Recherche pour le Développement, La Paz, Bolivia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Bolivia / epidemiology
Chagas Disease / diagnosis*,  epidemiology,  physiopathology*,  transmission
Female
Humans
Infant, Newborn
Infant, Newborn, Diseases / epidemiology,  parasitology*
Pregnancy
Prevalence
Serologic Tests
Trypanosoma cruzi / isolation & purification*
Umbilical Cord / parasitology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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