Document Detail


Congenital acute myeloid leukemia with t(8;16) and t(17;19) double translocation: case presentation and literature review.
MedLine Citation:
PMID:  20514319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Congenital leukemia is uncommon and excluding transient myeloproliferation associated with Down syndrome, makes up approximately 1% of childhood leukemias. A newborn boy was born with multiple subcutaneous nodules and large purpuric papules. Skin biopsy revealed proliferation of atypical hematologic cells in the dermis. Bone marrow morphology was consistent with acute myeloid leukemia (M5) and cytogenetic studies revealed t(8;16) and t(17;19) double translocation. Although prognosis of congenital leukemia is known to be dismal, recent reports showed spontaneous remissions. With the fear of chemotherapy-related toxicity, to treat or not to treat may be a dilemma both to parents and pediatricians. We report our experience and review the literature.
Authors:
Tae-Jung Sung; Dae-Hyoung Lee; Soon-Ki Kim; Yong-Hoon Jun
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-05-24
Journal Detail:
Title:  Journal of Korean medical science     Volume:  25     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2010-09-08     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  945-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, College of Medicine, Hallym University Medical Center, Seoul, Korea. neosung@hallym.or.kr
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 8
Humans
Immunophenotyping
Infant, Newborn
Karyotyping
Leukemia, Myeloid, Acute / diagnosis,  genetics*
Male
Translocation, Genetic*
Comments/Corrections

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