Document Detail

Confusional symptomatology distinguishes early- and late-onset Alzheimer's disease.
MedLine Citation:
PMID:  2094379     Owner:  NLM     Status:  MEDLINE    
Symptoms of confusion were examined in 75 patients with Alzheimer's disease (AD). Mild confusion was found in 20, and mode-rate/severe confusion in 8 patients. Confusion was more frequent in the late-onset (26/44-59%) than in the early-onset AD group (2/31-6%) (p less than 0.0001), and patients with confusion were older (p less than 0.0001) than those without confusion. The frequency of confusion was higher in patients with ischemic heart disease (13/28-46%) than in patients without this vascular factor (10/47-21%) (p less than 0.05). An inverse relation was found between confusional symptomatology and parietal-lobe symptoms. The findings in this study suggest that a subgroup of AD patients, fulfilling the NINCDS-ADRDA criteria for probable AD, is characterized by a clinical picture of mild confusional symptomatology together with no or mild parietal-lobe symptomatology, higher age and higher frequency of ischemic heart disease. This group contrasts with the other subgroup of pure AD, which is characterized by a clinical picture of marked parietal-lobe symptomatology, almost no confusional symptomatology, lower age and lower frequency of ischemic heart disease.
K Blennow; A Wallin; C G Gottfries
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Aging (Milan, Italy)     Volume:  2     ISSN:  0394-9532     ISO Abbreviation:  Aging (Milano)     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-07-02     Completed Date:  1991-07-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102503     Medline TA:  Aging (Milano)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  395-401     Citation Subset:  IM    
Department of Psychiatry and Neurochemistry, Gothenburg University, St. Jörgen's Hospital, Hisings Backa, Sweden.
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MeSH Terms
Alzheimer Disease / complications*,  physiopathology,  psychology
Brain Diseases / complications,  physiopathology
Confusion / etiology*
Middle Aged
Parietal Lobe / physiopathology
Time Factors

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