Document Detail


Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date.
MedLine Citation:
PMID:  24262603     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
There is currently a growing interest in docosahexaenoic acid (DHA) oxygenated metabolites. Among them, protectin D1 (PD1), an endogenous dihydroxylated and non cyclic docosatriene made through lipoxygenation and hydrolysis of an epoxide intermediate, shows appealing biological effects. However, with the present paper we wish to point out that results are sometimes assigned to PD1 while they are indeed related to its isomer protectin DX (PDX) made through double lipoxygenation only. These misleading conclusions urge us to review herein the structural/chemical and biological differences in the docosatrienes reported to date in the literature i.e. PD1, the related PD1 n-3 DPA, AT-NPD1, maresin 1 (MaR1) and MaR1 n-3 DPA, as well as their poxytrin analogs such as PDX, and some synthetic diastereoisomers. Hopefully, this will avoid further mistakes and confusion in the future.
Authors:
Laurence Balas; Michel Guichardant; Thierry Durand; Michel Lagarde
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-18
Journal Detail:
Title:  Biochimie     Volume:  -     ISSN:  1638-6183     ISO Abbreviation:  Biochimie     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1264604     Medline TA:  Biochimie     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Published by Elsevier Masson SAS.
Affiliation:
Institut des Biomolécules Max Mousseron (IBMM,UMR5247 CNRS-UM1-UM2-ENSCM), Faculté de Pharmacie, 15 av. C. Flahault, BP.14491, 34093 Montpellier Cedex 5, France. Electronic address: balas@univ-montp1.fr.
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