Document Detail


Confronting JC virus and Homo sapiens biological signatures.
MedLine Citation:
PMID:  23276955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present report describes the peptide commonality between JC virus (JCV) and the human proteome at the heptamer level. In total, 53 viral heptapeptides occur in functionally important human proteins with potential consequences for host functions and JCV pathogenesis. A paradigmatic example of a crucial peptide match is the SGKTTLA sequence, shared by JCV LT antigen and human nicotinamide/nicotinic acid riboside kinase, an enzyme involved in myelination processes. In general, the JCV-versus-host heptapeptide overlap may result in a competition between viral sequences and identical motifs in host enzymic active sites, adhesive domains, regulatory signaling motifs, etc., thus interfering with essential reactions and posing disadvantages to the cell. Overall, this study provides a starting point for investigating the role of peptide commonality in host-pathogen interactions.
Authors:
Guglielmo Lucchese
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  716-24     Citation Subset:  IM    
Affiliation:
Department of Neurological and Psychiatric Sciences, University of Bari, P.za G. Cesare, Bari 70125, Italy. guglielmo.lucchese@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Cell Adhesion / genetics
GTPase-Activating Proteins / genetics
Host-Pathogen Interactions
Humans
JC Virus / genetics*
Nerve Net / chemistry
Oligopeptides / chemistry,  genetics*
Phosphotransferases (Alcohol Group Acceptor) / genetics
Protein Sorting Signals / genetics
Sequence Homology, Amino Acid*
Viral Proteins / genetics*
Chemical
Reg. No./Substance:
0/GTPase-Activating Proteins; 0/Oligopeptides; 0/Protein Sorting Signals; 0/RAP1GAP protein, human; 0/Viral Proteins; EC 2.7.1.-/Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.22/NMRK1 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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