Document Detail


Conformational stability of leukocyte lactate dehydrogenase in healthy men of different age.
MedLine Citation:
PMID:  23330087     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Comparative analysis of cytosolic fraction distribution and conformational stability in lactate dehydrogenase (LDH) isozymes in healthy men of different age revealed significant differences indicating age-related characteristics of the enzyme. Activity of cytosolic fraction of LDH-1 and conformational stability of LDH-2 and LDH-3 in 40-year-old men were higher than in 20-year-olds. These data suggest age-related determination of conformational stability of individual LDH isozymes and functional heterogeneity of the enzyme within each isoform.
Authors:
O Yu Fedorenko; N A Bokhan; S A Ivanova
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  154     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2013-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  44-6     Citation Subset:  IM    
Affiliation:
Mental Health Research Institute, Siberian division of Russian Academy of Medical Sciences, Tomsk, Russia. f_o_y@mail.ru.
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