| Conformational change in coronary artery structure assessed by optical coherence tomography in patients with vasospastic angina. | |
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MedLine Citation:
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PMID: 21958888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of this study was to investigate the conformational change of arterial structure in the vasospastic lesion with optical coherence tomography. BACKGROUND: Coronary artery spasm plays an important role in the pathogenesis of ischemic heart diseases. The conformational change of each arterial layer during vasospasm has not been studied in detail. METHODS: We assessed 19 coronary arteries (10 spasm and 9 nonspasm lesions) with optical coherence tomography during the provocation test for coronary spasm. An intimal bump was defined as 1 or more intimal projections into the lumen that disappeared after the administration of nitroglycerine (NTG). Intimal gathering was defined as a folding/gathering of the intima, resulting in multiple kinks in the luminal contour that resolved after the administration of NTG. RESULTS: The spasm lesion more frequently showed an intimal bump at baseline and intimal gathering during spasm compared with the nonspasm lesion (spasm 80% vs. nonspasm 0%, p < 0.01, spasm 100% vs. nonspasm 0%, p < 0.01, respectively). The spasm lesion demonstrated a thicker maximum media thickness (spasm 0.24 ± 0.04 mm vs. nonspasm 0.12 ± 0.03 mm, p < 0.01) at baseline, whereas no differences were observed after the administration of NTG (spasm 0.13 ± 0.03 mm vs. nonspasm 0.13 ± 0.02 mm, p = 0.65). CONCLUSIONS: Our results suggest that medial contraction occurs even in an asymptomatic state and facilitates the formation of an intimal bump in patients with vasospastic angina. Luminal narrowing during spasm is associated with intimal gathering without alteration of intimal area. |
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Authors:
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Atsushi Tanaka; Kenei Shimada; Guillermo J Tearney; Hironori Kitabata; Haruyuki Taguchi; Shota Fukuda; Manabu Kashiwagi; Takashi Kubo; Shigeho Takarada; Kumiko Hirata; Masato Mizukoshi; Junichi Yoshikawa; Brett E Bouma; Takashi Akasaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 58 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-30 Completed Date: 2012-01-05 Revised Date: 2012-04-13 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1608-13 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA. atanaka1@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Vasospasm / diagnosis*, pathology Coronary Vessels / pathology* Female Humans Male Middle Aged Tomography, Optical Coherence* |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 2012 Mar 13;59(11):1038-9; author reply 1039
[PMID:
22402078
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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