| Conformational analysis of nucleic acids revisited: Curves+. | |
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MedLine Citation:
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PMID: 19625494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe Curves+, a new nucleic acid conformational analysis program which is applicable to a wide range of nucleic acid structures, including those with up to four strands and with either canonical or modified bases and backbones. The program is algorithmically simpler and computationally much faster than the earlier Curves approach, although it still provides both helical and backbone parameters, including a curvilinear axis and parameters relating the position of the bases to this axis. It additionally provides a full analysis of groove widths and depths. Curves+ can also be used to analyse molecular dynamics trajectories. With the help of the accompanying program Canal, it is possible to produce a variety of graphical output including parameter variations along a given structure and time series or histograms of parameter variations during dynamics. |
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Authors:
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R Lavery; M Moakher; J H Maddocks; D Petkeviciute; K Zakrzewska |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-22 |
Journal Detail:
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Title: Nucleic acids research Volume: 37 ISSN: 1362-4962 ISO Abbreviation: Nucleic Acids Res. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-10-14 Completed Date: 2009-11-23 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 0411011 Medline TA: Nucleic Acids Res Country: England |
Other Details:
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Languages: eng Pagination: 5917-29 Citation Subset: IM |
Affiliation:
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Institut de Biologie et Chimie des Protéines, CNRS UMR 5086/Université de Lyon, 7 Passage du Vercors, 69367 Lyon, France. richard.lavery@ibcp.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Base Pairing DNA / chemistry Models, Molecular Nucleic Acid Conformation* Software* |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
| Comments/Corrections | |
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