Document Detail

Conformation-dependent chemical reaction of formic acid with an oxygen atom.
MedLine Citation:
PMID:  19569616     Owner:  NLM     Status:  MEDLINE    
Conformation dictates many physical and chemical properties of molecules. The importance of conformation in the selectivity and function of biologically active molecules is widely accepted. However, clear examples of conformation-dependent bimolecular chemical reactions are lacking. Here we consider a case of formic acid (HCOOH) that is a valuable model system containing the -COOH carboxyl functional group, similar to many biomolecules including the standard amino acids. We have found a strong case of conformation-dependent reaction between formic acid and atomic oxygen obtained in cryogenic matrices. The reaction surprisingly leads to peroxyformic acid only from the ground-state trans conformer of formic acid, and it results in the hydrogen-bonded complex for the higher-energy cis conformer.
Leonid Khriachtchev; Alexandra Domanskaya; Kseniya Marushkevich; Markku Räsänen; Bella Grigorenko; Alexander Ermilov; Natalya Andrijchenko; Alexander Nemukhin
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Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of physical chemistry. A     Volume:  113     ISSN:  1520-5215     ISO Abbreviation:  J Phys Chem A     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-17     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9890903     Medline TA:  J Phys Chem A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8143-6     Citation Subset:  IM    
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MeSH Terms
Formic Acids / chemistry*
Hydrogen Bonding
Models, Molecular
Molecular Conformation*
Oxygen / chemistry*
Spectroscopy, Fourier Transform Infrared
Reg. No./Substance:
0/Formic Acids; 64-18-6/formic acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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