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MedLine Citation:
PMID:  21605108     Owner:  NLM     Status:  Publisher    
Background:  lichen planus pilaris (LPP), and discoid lupus erythematosus (DLE) are the most common causes of lymphocytic primary cicatricial alopecias. The management of scarring alopecias can be difficult. Combination of clinic, dermoscopy and reflectance confocal microscopy (RCM), a non-invasive, high-resolution imaging technique, have been already demonstrated to be useful for choosing the correct biopsy site in patients with inflammatory skin diseases and obtaining microscopic diagnostic criteria. Objectives:  we evaluated the real usefulness of RCM for identification of criteria for LPP and DLE involving the scalp and their management during therapeutical follow-up. Methods:  7 caucasian patients, with previously histological established diagnosis of DLE (3) and LPP (4), were included in the study. RCM criteria for primary scarring alopecias were selected: epidermal disarray, spongiosis, exocytosis of inflammatory cells in the epidermis, interface dermatitis, peri-intra adnexal infiltration of inflammatory cells, dilated vessels in the dermis, dermal infiltration of inflammatory cells, melanophages and dermal sclerosis. All patients were followed-up using RCM during the treatment. During follow-up the RCM evolution of the epidermal, junctional and dermal inflammation have been evaluated. Results:  a series of RCM features of scalp LPP and DLE were identified showing correlation with histopathologic evaluation. During the treatment follow-up of the cases RCM demonstrated to be sensitive in the identification of therapeutical response. Conclusion:  in our preliminary study it seems to be evident the effective usefulness of RCM for scarring alopecias diagnosis and follow-up. Moreover, RCM seems to be also promising for differential diagnosis between the different entities.
M Agozzino; A Tosti; L Barbieri; E Moscarella; C Cota; E Berardesca; M Ardigò
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-23
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 British Association of Dermatologists.
San Gallicano Dermatological Institute-IRCCS, RomeDepartment of Dermatology & Cutaneous Surgery, Miller School of Medicine, University of Miami.
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