Document Detail

Conflicting levels of selection in the accumulation of mitochondrial defects in Saccharomyces cerevisiae.
MedLine Citation:
PMID:  11891344     Owner:  NLM     Status:  MEDLINE    
The somatic accumulation of defective mitochondria causes human degenerative syndromes, senescence in fungi, and male sterility in plants. These diverse phenomena may result from conflicts between natural selection at different levels of organization. Such conflicts are fundamental to the evolution of cooperating groups, from cells to populations. We present a model in which defective mitochondrial genomes accumulate because of a within-cell replication advantage when among-cell selection for efficient respiration is relaxed. We tested the model by using experimental populations of the yeast Saccharomyces cerevisiae. We constructed yeast strains that were heteroplasmic for mitochondrial mutations that destroy the ability to respire (the petite phenotype) and followed the accumulation of mitochondrial defects in cultures with different effective population sizes. As predicted by the model, the inability to respire evolved only in small populations of S. cerevisiae, where among-cell selection favoring cells that can respire was reduced relative to within-cell selection favoring parasitic mitochondria. In a control experiment, mitochondrial point mutations that confer resistance to chloramphenicol showed no tendency to change in frequency under any culture conditions. The accumulation of some mitochondrial defects is therefore an evolutionary process, involving multiple levels of selection. The relative intensities of within- and among-cell selection may also explain the tissue specificity of human mitochondrial defects.
Douglas R Taylor; Clifford Zeyl; Erin Cooke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2002-03-12
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  99     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-20     Completed Date:  2002-04-24     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3690-4     Citation Subset:  IM    
Department of Biology, University of Virginia, Charlottesville, VA 22904-4328, USA.
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MeSH Terms
Cell Respiration / drug effects
Chloramphenicol / pharmacology
DNA, Mitochondrial / genetics*
Drug Resistance, Fungal
Evolution, Molecular
Mitochondria / drug effects,  genetics*,  metabolism,  pathology*
Models, Biological
Mutation / genetics
Saccharomyces cerevisiae / cytology*,  drug effects,  genetics*
Selection, Genetic*
Reg. No./Substance:
0/DNA, Mitochondrial; 56-75-7/Chloramphenicol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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