| Confirmatory tests in the diagnosis of primary aldosteronism. | |
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MedLine Citation:
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PMID: 20119882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary aldosteronism is the most common form of secondary hypertension and patients with hyperaldosteronism are more prone to premature cardiovascular complications compared to essential hypertensives. The diagnostic flow-chart for the diagnosis of PA is performed in three steps: a) screening; b) confirmation; and c) subtype differentiation. Instead of proceeding directly to subtype classification, the recently published Endocrine Society Guidelines recommend that patients with a positive ARR should undergo a confirmatory test, in order to definitively confirm or exclude the diagnosis of PA. The Guidelines recognize four testing procedures: oral sodium loading, saline infusion, fludrocortisone suppression, and captopril challenge. Herein we discuss the diagnostic protocols for these confirmatory tests and highlight both the advantages and contraindications and we discuss studies in which these confirmatory tests have been compared. |
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Authors:
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P Mulatero; S Monticone; C Bertello; G Mengozzi; D Tizzani; A Iannaccone; F Veglio |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-01-29 |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 42 ISSN: 1439-4286 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-26 Completed Date: 2010-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 406-10 Citation Subset: IM |
Copyright Information:
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Georg Thieme Verlag KG Stuttgart-New York. |
Affiliation:
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Division of Internal Medicine, Department of Medicine and Experimental Oncology, University of Torino, Torino, Italy. paolo.mulatero@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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analysis Algorithms Diagnostic Techniques, Endocrine* / standards Fludrocortisone / diagnostic use Humans Hyperaldosteronism / diagnosis* Renin / analysis Sodium, Dietary / diagnostic use Validation Studies as Topic* |
| Chemical | |
Reg. No./Substance:
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0/Sodium, Dietary; 127-31-1/Fludrocortisone; 52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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