Document Detail

Confirmation of neonatal screening: reference intervals and evaluation of methodological changes in TSH measurement.
MedLine Citation:
PMID:  21073118     Owner:  NLM     Status:  MEDLINE    
Neonatal reference values for serum thyrotropin are scarce and comprise only small numbers of patients. During 2006, changes were made in IMMULITE kits for TSH measurement. To validate methodological changes, 80 serum samples from patients were evaluated and to establish reference intervals, 334 neonates and infants were analyzed (divided into 4 groups). Group 1 (G1) (48-72 h of life) (n=153), group 2A (G2A) (7-10 days of life) (n=65), group 2B (G2B) (11-14 days of life) (n=35), group 3 (G3) (28-40 days of life) (n=81). Current kits overestimate TSH results by 26 to 37%; TSH (mIU/L) reference intervals (percentile 2.5-97.5) were G1 (1.1-12.7), G2A (1.8-9.8), G2B (1.1-7.1) (p < 0.03 vs. G2A), G3 (1.2-6.9). We suggest that during the second week of life, reference values should be divided into an early stage and a late stage, at least, for there to be an adequate interpretation of borderline measurements in newborn thyroid screening.
Gabriel Fideleff; Martha G Suárez; Patricia G V Sobrado; Maria L Celadilla; Mario Mardyks; Carmen C Rodriguez; Ana Jelen; Hugo R Boquete; Hugo L Fideleff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  23     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2010-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  759-64     Citation Subset:  IM    
Endocrinology Unit, Department of Medicine, Hospital V. Sarsfield, Buenos Aires, Argentina.
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MeSH Terms
Clinical Chemistry Tests / methods,  statistics & numerical data
Infant, Newborn
Neonatal Screening / methods*
Reagent Kits, Diagnostic*
Reference Values
Thyroid Hormones / blood
Thyrotropin / blood*
Reg. No./Substance:
0/Reagent Kits, Diagnostic; 0/Thyroid Hormones; 9002-71-5/Thyrotropin

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