| Confirmation of eprinomectin, moxidectin, abamectin, doramectin, and ivermectin in beef liver by liquid chromatography/positive ion atmospheric pressure chemical ionization mass spectrometry. | |
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MedLine Citation:
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PMID: 10693003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A liquid chromatographic (LC) multiresidue screening procedure was developed for determination of eprinomectin, moxidectin, abamectin, doramectin, and ivermectin in beef liver at 0, 25, 50, and 100 ppb levels. A procedure using low resolution LC/atmospheric pressure chemical ionization (APCI) mass spectrometry (MS) was developed with further purification steps added to the quantitative LC method to confirm residues. Acetonitrile extracts of liver, prior to derivatization for LC analysis, were further purified by using a C8 solid-phase extraction cartridge and an alumina-B cartridge. The purified extract was analyzed by injection into an LC/positive ion APCI MS. Identity of the compound was confirmed by comparison of its retention time and relative intensity data with those of a standard or recovery from a fortified control liver sample. Anthelmintic drugs in acetonitrile extracts of liver containing eprinomectin, moxidectin, abamectin, doramectin, and ivermectin at 25 ppb, the lowest level of fortification used in the LC determinative method, were successfully confirmed. |
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Authors:
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M S Ali; T Sun; G E McLeroy; E T Phillippo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of AOAC International Volume: 83 ISSN: 1060-3271 ISO Abbreviation: J AOAC Int Publication Date: 2000 Jan-Feb |
Date Detail:
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Created Date: 2000-03-16 Completed Date: 2000-03-16 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 9215446 Medline TA: J AOAC Int Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 39-52 Citation Subset: IM |
Affiliation:
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U.S. Department of Agriculture, Food Safety and Inspection Service, Atlanta, GA 30604, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anthelmintics / analysis* Anti-Bacterial Agents / analysis Antinematodal Agents / analysis Cattle Chromatography, Liquid / methods* Drug Residues / analysis Food Contamination Ivermectin / analogs & derivatives*, analysis* Liver / chemistry* Macrolides Mass Spectrometry / methods Quality Control |
| Chemical | |
Reg. No./Substance:
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0/Anthelmintics; 0/Anti-Bacterial Agents; 0/Antinematodal Agents; 0/Macrolides; 117704-25-3/doramectin; 160902-72-7/4''-epiacetylamino-4''-deoxyavermectin B1; 51570-36-6/milbemycin; 70288-86-7/Ivermectin; 71751-41-2/abamectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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