Document Detail


Confirmation of avermectin residues in food matrices with negative-ion atmospheric pressure chemical ionization liquid chromatography/mass spectrometry.
MedLine Citation:
PMID:  10204245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A multi-residue LC/MS method has been developed to confirm avermectin drug residues in several food matrices. Ivermectin (IVR), doramectin (DOR), eprinomectin (EPR) and moxidectin (MOX) are confirmed using atmospheric pressure chemical ionization (APCI) with negative ion detection and selected ion monitoring of three to four ions for each compound. The drug residues are extracted from tissue or milk using previously published procedures. IVR and DOR are confirmed at 20 ppb levels in fortified salmon muscle; IVR is also confirmed in tissue from salmon dosed with the drug. Residues of DOR, IVR, and EPR are confirmed in fortified milk at the 20 ppb level and in fortified beef liver at 40 ppb. Residues of MOX can also be confirmed in these matrices, but at slightly higher levels (40-80 ppb).
Authors:
S B Turnipseed; J E Roybal; H S Rupp; S A Gonzales; A P Pfenning; J A Hurlbut
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rapid communications in mass spectrometry : RCM     Volume:  13     ISSN:  0951-4198     ISO Abbreviation:  Rapid Commun. Mass Spectrom.     Publication Date:  1999  
Date Detail:
Created Date:  1999-05-26     Completed Date:  1999-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802365     Medline TA:  Rapid Commun Mass Spectrom     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  493-9     Citation Subset:  IM    
Affiliation:
Animal Drugs Research Center, Food and Drug Administration, Denver, CO 80225-0087, USA. sturnips@ora.fda.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthelmintics / analysis*
Cattle
Gas Chromatography-Mass Spectrometry
Ivermectin / analogs & derivatives*,  analysis
Liver / chemistry
Meat / analysis*
Milk / chemistry*
Pesticide Residues / analysis*
Salmon / metabolism*
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Pesticide Residues; 117704-25-3/doramectin; 70288-86-7/Ivermectin; 73989-17-0/avermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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