| Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease. | |
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MedLine Citation:
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PMID: 9633759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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C766T, a polymorphism in exon 3 of the gene for the low-density lipoprotein receptor-related protein (LRP), was found to be associated with late-onset Alzheimer's disease (AD). We developed a PCR-restriction enzyme-based assay to analyze this allele in 234 AD patients and 103 controls. We confirmed that the LRP C766T polymorphism was in disequilibrium with AD--the C/C genotype was present in 76% of AD patients and 60% of controls (p < 0.01); however, the LRP polymorphism did not influence age at onset of AD. |
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Authors:
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E Hollenbach; S Ackermann; B T Hyman; G W Rebeck |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurology Volume: 50 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-07-09 Completed Date: 1998-07-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1905-7 Citation Subset: AIM; IM |
Affiliation:
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Alzheimer's Research Unit, Massachusetts General Hospital, Charlestown 02129, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Aging / physiology Alleles Alzheimer Disease / genetics* Apolipoproteins E / genetics Child Exons / genetics* Gene Frequency Genotype Humans LDL-Receptor Related Protein 1 Middle Aged Polymorphism, Genetic / genetics* Receptors, Immunologic / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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AG05134/AG/NIA NIH HHS; AG12406/AG/NIA NIH HHS; AG14473/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/LDL-Receptor Related Protein 1; 0/Receptors, Immunologic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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