| Confirmation of LRRK2 S1647T variant as a risk factor for Parkinson's disease in southern China. | |
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MedLine Citation:
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PMID: 20629711 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) S1647T has been identified as a risk variant for Parkinson's disease (PD) in Han Chinese. METHODS: To replicate the association of LRRK2 S1647T with risk of PD, we conducted a case-control study of this variant involving 406 PD subjects and 412 controls from southern mainland China. RESULTS: The results showed that the frequency of A allele was higher in patients with PD (OR=1.238, 95% CI: 1.015-1.510, P=0.035) compared to controls. In a multivariate logistic regression analysis with the disease group (patients with PD vs. controls) as the dependent variable and genotype as an independent factor adjusting for the effect of age and gender, the homozygous S1647T genotype (AA) was associated with an increased risk of PD (OR=1.815, 95% CI:1.270-2.594, P=0.001). The pooled analysis of present data and the data from the previous work demonstrated that the frequency of A allele was higher in patients with PD (OR=1.2, 95% CI: 1.09-1.32, P<0.0001). CONCLUSIONS: LRRK2 S1647T increases the risk of Parkinson's disease in southern China. |
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Authors:
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Y Zheng; Y Liu; Q Wu; H Hong; H Zhou; J Chen; H Wang; W Xian; J Li; Z Liu; Z Pei; L Chen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 18 ISSN: 1468-1331 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-17 Completed Date: 2011-05-31 Revised Date: 2012-06-25 |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 538-40 Citation Subset: IM |
Copyright Information:
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© 2010 The Author(s). European Journal of Neurology © 2010 EFNS. |
Affiliation:
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Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Asian Continental Ancestry Group / genetics China Female Gene Frequency Genetic Predisposition to Disease / genetics* Genotype Humans Male Middle Aged Parkinson Disease / genetics* Polymerase Chain Reaction Polymorphism, Single Nucleotide / genetics* Protein-Serine-Threonine Kinases / genetics* Risk Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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EC 2.7.11.1/LRRK2 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
| Comments/Corrections | |
Comment In:
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Eur J Neurol. 2011 Mar;18(3):369-70
[PMID:
20629720
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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