Document Detail


Confinement to the open arm of the elevated-plus maze as anxiety paradigm: behavioral validation.
MedLine Citation:
PMID:  16768623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exposure to the open arm of the elevated-plus maze was used to assess the neurobiological correlates of anxiety in the high-anxiety-related behavior (HAB) and low-anxiety-related behavior (LAB) rat lines. The authors sought to determine whether this mild stressor could be considered a valuable anxiety test revealing specific behavioral differences. Behavioral parameters scored were submitted to a discriminant and factor analysis to investigate emotional parameters discriminating HAB and LAB rats. Principal component analysis showed that the HAB rats' behavior was driven by anxiety, whereas the LAB rats' behavior was mainly explained by locomotor activity. Moreover, the rats displayed behaviors that reflected distinct coping strategies confirming anxiogenic open arm effects and differential appraisals of the stressor dependent on the genetic predisposition to either hyper- or hypo-anxiety.
Authors:
Nicolas Salomé; Rainer Landgraf; Odile Viltart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  120     ISSN:  1939-0084     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2009-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  719-23     Citation Subset:  IM    
Copyright Information:
Copyright 2006 APA, all rights reserved.
Affiliation:
Unité de Neurosciences et de Physiologie adaptatives, Equipe Stress Périnatal, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anxiety / diagnosis*,  genetics,  physiopathology*
Behavior, Animal / physiology*
Discriminant Analysis
Disease Models, Animal
Male
Maze Learning / physiology*
Motor Activity / physiology
Principal Component Analysis
Rats
Rats, Wistar
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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