Document Detail


Confined placental mosaicism and pregnancy outcome: a distinction needs to be made between types 2 and 3.
MedLine Citation:
PMID:  20936639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study the influence of types 2 and 3 confined placental mosaicism (CPM) on pregnancy outcome.
METHOD: From 13 809 chorionic villus samplings (CVSs), karyotype after long-term cultured villi (LTC-villi) was systematically performed. Next, in case of suspicion of CPM, karyotype after short-term cultured villi (STC-villi) was established to define type 2 CPM (chromosomal abnormality limited to the mesenchymal core) or type 3 CPM (chromosomal abnormality found both in the cytotrophoblast and the mesenchymal core). Confirmatory amniocentesis was performed to exclude fetal mosaicism. Uniparental disomy (UPD) testing was carried out when the abnormal cell line involved chromosomes 5, 6, 7, 15 or 16.
RESULTS: Fifty-seven CPM cases were observed (57/13 809 = 0.41%) and of these, 37 were type 2 and 20 were type 3 CPM. Incidence of preterm infants, neonatal hypotrophy and adverse pregnancy outcome were comparable between patients in whom type 2 CPM was demonstrated and the control population. In contrast, for the type 3 CPM the incidence of these factors was higher than for the control population.
CONCLUSION: When a CPM is suspected, it appears essential to determine type, since type 2 has no effect on fetal development and type 3 is associated with preterm infants, low birth weight and adverse pregnancy outcome.
Authors:
Jérôme Toutain; Cécile Labeau-Gaüzere; Thomas Barnetche; Jacques Horovitz; Robert Saura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  30     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  2011-03-31     Revised Date:  2013-04-10    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  1155-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Affiliation:
Department of Medical Genetics, Pellegrin University Hospitals (Maternity), Bordeaux, France. jerome.toutain@chu-bordeaux.fr
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MeSH Terms
Descriptor/Qualifier:
Abortion, Eugenic / statistics & numerical data
Adult
Aneuploidy
Chorionic Villi Sampling / statistics & numerical data
Chromosome Aberrations / statistics & numerical data
Down Syndrome / epidemiology,  genetics
Female
Humans
Infant, Newborn
Infant, Newborn, Diseases / epidemiology,  genetics
Mosaicism / classification*,  statistics & numerical data
Placenta / metabolism*
Pregnancy
Pregnancy Outcome / epidemiology,  genetics*
Retrospective Studies
Comments/Corrections
Comment In:
Prenat Diagn. 2013 Mar;33(3):303-4   [PMID:  23456997 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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