Document Detail

Confined placental mosaicism as a risk factor among newborns with fetal growth restriction.
MedLine Citation:
PMID:  16557641     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To delineate the frequency and clinical presentation of confined placental mosaicism (CPM) among newborns with idiopathic intrauterine growth restriction (IUGR) as compared to infants with appropriate fetal growth. METHODS: 70 newborns with IUGR (birth weight < 10%) were matched by maternal age (+/-5 years) and gestational age (+/-7 days) to an equal number of infants of normal size. From both populations, placental samples underwent karyotype analysis following standard culture. RESULTS: CPM occurred significantly more often in the placentas from IUGR infants compared to controls, 11/70 (15.7%) and 1/70 (1.4%) respectively (p = 0.008). High-level tetraploidy (>20% in a primary culture) predominated among the IUGR placentas, while autosomal aneuploidy occurred only once in each population. Placental histology revealed significantly greater decidual vasculopathy, infarction, and intervillous thrombus formation in the karyotypically abnormal placentas (p = 0.03). Maternal age, gestational age at delivery, degree of growth restriction and ponderal index did not vary with the presence of CPM. CONCLUSION: CPM, and principally high-level tetraploidy, is found significantly more often among the placentas of newborns with IUGR. Infants with IUGR and CPM are clinically diverse although the placentas display pathologic changes suggestive of chronic impairment of uteroplacental function.
Louise Wilkins-Haug; Bradley Quade; Cynthia C Morton
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  26     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-08     Completed Date:  2006-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  428-32     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2006 John Wiley & Sons, Ltd.
Division of Maternal Fetal Medicine and Reproductive Genetics, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA 02115, USA.
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MeSH Terms
Birth Weight
Decidua / blood supply,  pathology*
Fetal Growth Retardation / epidemiology*,  pathology*
Gestational Age
Infant, Newborn
Infarction / epidemiology,  pathology
Maternal Age
Risk Factors
Thrombosis / epidemiology,  pathology
Trophoblasts / pathology*

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