| Conference Scene: Environmental epigenomics and disease susceptibility. | |
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MedLine Citation:
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PMID: 22122336 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The main objective of this conference was to provide solid evidence that environmental exposures during early development can affect faithful reproduction of individual parental epigenomes without changing DNA sequence in the offspring. No doubt, this important goal has been successfully achieved owing to the high quality of presented epidemiological and experimental studies and engaging discussions of many yet to be published results. Compelling data suggested a strong causal link between prenatal vulnerability of future parental epigenomes to damaging environmental factors aggravated by abnormal socio-cultural conditions (including, for instance, malnutrition and chronic stress) and the alarming risk of developing heritable complex medical conditions later in life, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, schizophrenia and a whole range of rare neuromuscular pathologies. It was concluded that modern epigenetic research promises to markedly improve our ability to diagnose, prevent and treat these and other pathological conditions of humans. However, the complex heritability pattern of 'epigenetic syndromes' also introduces unique legal and ethical issues that were discussed at the end of this outstanding meeting. |
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Authors:
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Victor Lobanenkov; Dmitry Loukinov; Elena Pugacheva |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Epigenomics Volume: 3 ISSN: 1750-192X ISO Abbreviation: Epigenomics Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101519720 Medline TA: Epigenomics Country: England |
Other Details:
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Languages: eng Pagination: 261-6 Citation Subset: IM |
Affiliation:
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Molecular Pathology Section, Laboratory of Immunopathology, National Institutes of Allergy & Infectious Disease, Twinbrook I, Room 1417, MSC-8152, 5640 Fishers Lane, Rockville, MD 20852, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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