Document Detail


Cone-rod dystrophy. Phenotypic diversity by retinal function testing.
MedLine Citation:
PMID:  2719580     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three patterns of visual dysfunction were identified in patients with autosomal recessive or simplex cone-rod dystrophy using rod and cone electroretinography and light- and dark-adapted static threshold perimetry. In the first pattern, there was a central rod and cone scotoma with eccentric fixation, mild peripheral retinal dysfunction equally affecting rod and cone systems, and slow progression. The second pattern, which was relatively more severe, also showed a central rod and cone scotoma and eccentric fixation; however, there was more cone than rod dysfunction detected by electroretinography, and function was lost in the peripheral visual field before it was lost in the midperipheral field. A third pattern, which was rapidly progressive, showed central unsteady fixation and no measurable cone function. Patches of rod function were retained in the central and inferotemporal regions of the visual field. Most of the patients studied fit within the three patterns and the patterns were consistent within families.
Authors:
K Yagasaki; S G Jacobson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  107     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-16     Completed Date:  1989-06-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  701-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33101.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Dark Adaptation
Electroretinography
Female
Humans
Male
Middle Aged
Perimetry
Phenotype
Photoreceptor Cells
Psychophysics / methods
Retina / physiopathology*
Retinitis Pigmentosa / genetics,  physiopathology*
Sensory Thresholds
Grant Support
ID/Acronym/Agency:
EY05627/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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