Document Detail

Cone location dependent outcomes after combined topography-guided photorefractive keratectomy and collagen crosslinking.
MedLine Citation:
PMID:  25461261     Owner:  NLM     Status:  Publisher    
PURPOSE: To evaluate the effect of the keratoconus (KC) cone location on the change in refractive outcomes, corneal aberrations and biomechanics after combined topography-guided photorefractive keratectomy (PRK) and collagen crosslinking (CXL).
DESIGN: Prospective, comparative case series METHODS: Topography guided PRK was performed followed by accelerated CXL using riboflavin A and enhanced intensity (30mW/cm(2)) ultraviolet light. Outcome parameters including uncorrected distance visual acuity (UDVA) and best corrected distance visual acuity (BDVA), corneal tomography and biomechanics (corneal hysteresis [CH] and corneal resistance factor [CRF]), and corneal wavefront aberrations were assessed before and a year after the procedure. Eyes were subdivided into two groups preoperatively: group 1 - cone located within the central 2 mm zone and group 2 - cone located outside the central 2 mm zone for statistical analysis.
RESULTS: UDVA, BDVA, sphere, cylinder and simulated keratometry improved after treatment in both groups (p<0.05). However, BDVA improved more in group 1 than in 2 (p=0.04) and the other variables were not affected by cone location. A few corneal wavefront Zernike aberrations changed after treatment (p<0.05) but none were affected by cone location (p>0.05). CH and CRF increased after treatment in both groups (p>0.05). Interestingly, the increases in CH and CRF were greater in group 2 than in 1 (p>0.05).
CONCLUSIONS: Cone location appeared to impact only visual acuity and biomechanics after the combined procedure. The greater increase in CH and CRF in group 2 may indicate differences in the ablation profile and variability in CXL outcomes and requires further study.
Rohit Shetty; Rudy M M A Nuijts; Maneck Nicholson; Koushik Sargod; Chaitra Jaidev; Himabindu Veluri; Abhijit Sinha Roy
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-18
Journal Detail:
Title:  American journal of ophthalmology     Volume:  -     ISSN:  1879-1891     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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