Document Detail

Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis.
MedLine Citation:
PMID:  12681865     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the risk of juvenile-onset recurrent respiratory papillomatosis conferred by a maternal history of genital warts in pregnancy, and to identify additional cofactors such as the method of delivery (cesarean versus vaginal) and procedures or complications during pregnancy. METHODS: A retrospective cohort design was used to evaluate maternal and infant characteristics associated with respiratory papillomatosis among Danish births between 1974 and 1993. Using data from Danish registries, we identified 3033 births with a maternal history of genital warts during pregnancy. Fifty-seven respiratory papillomatosis cases were identified by review of medical records from ear, nose, and throat departments. RESULTS: Seven of every 1000 births with a maternal history of genital warts resulted in disease in the offspring, corresponding to a 231.4 (95% confidence interval 135.3, 395.9) times higher risk of disease relative to births without a maternal history of genital warts. In women with genital warts, delivery times of more than 10 hours were associated with a two-fold greater risk of disease. Cesarean delivery was not found to be protective against respiratory papillomatosis, and no other procedures or complications during pregnancy were observed to increase the risk of respiratory papillomatosis. CONCLUSION: A maternal history of genital warts in pregnancy is the strongest risk factor for respiratory papillomatosis in the child. Future studies should examine the efficacy of genital wart treatment for the prevention of disease.
Michael J Silverberg; Poul Thorsen; Henning Lindeberg; Linda A Grant; Keerti V Shah
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  101     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-08     Completed Date:  2003-04-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  645-52     Citation Subset:  AIM; IM    
Department of Epidemiology, Baltimore, Maryland 21205-2179, USA.
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MeSH Terms
Cohort Studies
Condylomata Acuminata*
Delivery, Obstetric / statistics & numerical data
Denmark / epidemiology
Infant, Newborn
Infectious Disease Transmission, Vertical*
Laryngeal Neoplasms / epidemiology*,  etiology*
Papilloma / epidemiology*,  etiology*
Predictive Value of Tests
Pregnancy Complications, Infectious*
Retrospective Studies
Risk Factors
Time Factors
Grant Support
R03 CA86170-01/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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