Document Detail


Condyloma acuminatum in a cynomolgus monkey (Macaca fascicularis).
MedLine Citation:
PMID:  11487237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Condyloma acuminatum was found on the penile shaft and glans of a wild-caught cynomolgus monkey. The characteristic cauliflower-like, digitated lesions corresponded histopathologically with epidermal hyperplasia, hyperkeratosis, hypergranulosis, pallor of the mid-spinous zone, and crowding of keratinocytes. Electron microscopy revealed 10 intranuclear viral particles. In situ hybridization studies using human DNA probes (pan-Human Papillomavirus [HPV] 6/11, HPV 16/18, and HPV 31/33) all failed to hybridize. Polymerase chain reaction using papillomavirus probes MY09, MY11, GP5, and GP6 failed to amplify HPV DNA. We conclude that this lesion likely is a viral-induced condyloma but that the virus is not detectable by using presently available human or monkey papillomavirus probes.
Authors:
H P Gordon; D A Reim; S A McClain
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science     Volume:  39     ISSN:  1060-0558     ISO Abbreviation:  Contemp Top Lab Anim Sci     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2001-08-06     Completed Date:  2001-08-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9204153     Medline TA:  Contemp Top Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  30-3     Citation Subset:  IM    
Affiliation:
The Division of Laboratory Animal Resources and Department of Dermatology, State University of New York at Stony Brook, Stony Brook, NY 11794-8611, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Nucleus / ultrastructure,  virology
Condylomata Acuminata / pathology,  veterinary*,  virology
DNA, Viral / analysis
Humans
In Situ Hybridization / veterinary
Keratinocytes / ultrastructure,  virology
Macaca fascicularis*
Male
Microscopy, Electron / veterinary
Monkey Diseases / pathology*,  virology
Penile Diseases / pathology,  veterinary*,  virology
Polymerase Chain Reaction / veterinary
Virion / ultrastructure
Chemical
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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