| Condyloma acuminatum in a cynomolgus monkey (Macaca fascicularis). | |
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MedLine Citation:
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PMID: 11487237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Condyloma acuminatum was found on the penile shaft and glans of a wild-caught cynomolgus monkey. The characteristic cauliflower-like, digitated lesions corresponded histopathologically with epidermal hyperplasia, hyperkeratosis, hypergranulosis, pallor of the mid-spinous zone, and crowding of keratinocytes. Electron microscopy revealed 10 intranuclear viral particles. In situ hybridization studies using human DNA probes (pan-Human Papillomavirus [HPV] 6/11, HPV 16/18, and HPV 31/33) all failed to hybridize. Polymerase chain reaction using papillomavirus probes MY09, MY11, GP5, and GP6 failed to amplify HPV DNA. We conclude that this lesion likely is a viral-induced condyloma but that the virus is not detectable by using presently available human or monkey papillomavirus probes. |
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Authors:
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H P Gordon; D A Reim; S A McClain |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science Volume: 39 ISSN: 1060-0558 ISO Abbreviation: Contemp Top Lab Anim Sci Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2001-08-06 Completed Date: 2001-08-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9204153 Medline TA: Contemp Top Lab Anim Sci Country: United States |
Other Details:
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Languages: eng Pagination: 30-3 Citation Subset: IM |
Affiliation:
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The Division of Laboratory Animal Resources and Department of Dermatology, State University of New York at Stony Brook, Stony Brook, NY 11794-8611, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Nucleus / ultrastructure, virology Condylomata Acuminata / pathology, veterinary*, virology DNA, Viral / analysis Humans In Situ Hybridization / veterinary Keratinocytes / ultrastructure, virology Macaca fascicularis* Male Microscopy, Electron / veterinary Monkey Diseases / pathology*, virology Penile Diseases / pathology, veterinary*, virology Polymerase Chain Reaction / veterinary Virion / ultrastructure |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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