Document Detail


Conduit diameter and wall remodeling in elite athletes and spinal cord injury.
MedLine Citation:
PMID:  22508165     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: This study aimed to investigate localized and systemic effects of chronic exercise and inactivity on conduit artery remodeling in humans.
METHODS: We recruited elite athletes engaged in predominantly lower limb (LL runners/cyclists, n = 10) or upper limb (UL canoe paddlers, n = 12) exercise and matched able-bodied, recreationally active, controls (C, n = 16). We also studied wheelchair controls (spinal cord injury, n = 9) and athletes (spinal cord injury, n = 1; spina bifida, n = 4). Carotid, brachial, and superficial femoral (SF) artery diameter and wall thickness were assessed using high-resolution ultrasound.
RESULTS: Brachial diameters were significantly larger in UL and wheelchair users (athletes and controls) compared with C (both P < 0.05). SF artery diameter in wheelchair controls was significantly smaller compared with the other groups, with LL athletes having significantly greater lumen diameter than controls (both P < 0.05). In all arteries, a lower wall thickness was found in able-bodied athletes compared with C, including wheelchair athletes compared with wheelchair controls (P < 0.001). In the SF artery, wall-to-lumen-ratio was significantly lower in able-bodied athletes and higher in wheelchair controls compared with able-bodied controls (P < 0.001). In the brachial and carotid arteries, able-bodied and wheelchair athletes demonstrated lower wall-to-lumen-ratio than less active wheelchair controls and able-bodied controls (P < 0.001).
CONCLUSIONS: These findings suggest that remodeling of the arterial wall occurs systemically in response to exercise training and is unrelated to exercise type in humans. Conversely, localized effects are evident with respect to the effect of exercise on arterial diameter. These findings have implications for our understanding of the effects of exercise on arterial structure and function in humans.
Authors:
Nicola Jayne Rowley; Ellen Adele Dawson; Maria T E Hopman; Keith P George; Greg P Whyte; Dick H J Thijssen; Daniel John Green
Related Documents :
1521955 - Cardiac responses of young women to conditioning for a 10 kilometer race.
3386505 - Effect of 6 d of exercise training on responses to maximal and sub-maximal exercise in ...
18276405 - Adaptive ho-kashyap rules for perceptron training.
18298635 - Changes in the contractile properties of motor units in the rat medial gastrocnemius mu...
22252545 - Theory-based predictors of follow-up exercise behavior after a supervised exercise inte...
8112905 - St-changes in ecg at rest or during exercise indicate a high risk of severe coronary le...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  44     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  844-9     Citation Subset:  IM; S    
Affiliation:
1Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UNITED KINGDOM; 2Department of Physiology, Radboud University Nijmegen Medical Centre, Radboud, THE NETHERLANDS; and 3School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, WESTERN AUSTRALIA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Virus-drug interactions-molecular insight into immunosuppression and HCV.
Next Document:  Two-year course of subfoveal pigment epithelial detachment in eyes with age-related macular degenera...