| Conduit Diameter and Wall Remodelling In Elite Athletes and Spinal Cord Injury. | |
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MedLine Citation:
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PMID: 22051573 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE:: To investigate localised and systemic effects of chronic exercise and inactivity on conduit artery remodelling in humans. METHODS:: We recruited elite athletes engaged in predominantly lower limb (LL runners/cyclists, n=10) or upper limb (UL canoe paddlers, n=12) exercise and matched able-bodied, recreationally active, controls (C, n=16). We also studied wheelchair controls (spinal cord injury; n=9) and athletes (spinal cord injury; n=1, spina bifida; n=4). Carotid, brachial and superficial femoral artery diameter and wall thickness were assessed using high-resolution ultrasound. RESULTS:: Brachial diameters were significantly larger in UL and wheelchair-users (athletes and controls) compared to C (both P<0.05). Superficial femoral (SF) artery diameter in wheelchair-controls was significantly smaller compared to the other groups, with LL athletes having significantly greater lumen diameter than controls (both P<0.05). In all arteries, a lower wall thickness was found in able-bodied athletes compared to C, including wheelchair athletes compared to wheelchair controls (P<0.001). In the superficial femoral artery, wall-to-lumen-ratio was significantly lower in able-bodied athletes, and higher in wheelchair controls, compared to able-bodied controls (P<0.001). In the brachial and carotid arteries, ablebodied and wheelchair-athletes demonstrated lower wall-to-lumen-ratio than less active wheelchair-controls and able bodies controls (P<0.001). CONCLUSION:: These findings suggest that remodelling of the arterial wall occurs systemically in response to exercise training and is unrelated to exercise type in humans. Conversely, localised effects are evident with respect to the impact of exercise on arterial diameter. These findings have implications for our understanding of the effects of exercise on arterial structure and function in humans. |
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Authors:
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Nicola J Rowley; Ellen A Dawson; Maria T E Hopman; Keith George; Greg P Whyte; Dick H J Thijssen; Daniel J Green |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-2 |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: - ISSN: 1530-0315 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool L3 3AF, United Kingdom 2Department of Physiology, Radboud University Nijmegen Medical Centre, The Netherlands 3School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, Western Australia, 6009. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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