Document Detail

Conduction and excitability properties of peripheral nerves in end-stage liver disease.
MedLine Citation:
PMID:  17387740     Owner:  NLM     Status:  MEDLINE    
The pathophysiology of hepatic neuropathy is poorly understood, but membrane depolarization due to a toxic inhibition of oxidative metabolism has been proposed. We investigated the relationship between nerve excitability properties, nerve dysfunction, and liver function in 11 pretransplant patients, the majority of whom were oligo- or asymptomatic for peripheral neuropathy. Abnormalities were detected on clinical examination (6), large-fiber nerve conduction (4), and thermal quantitative sensory testing (10). Small-fiber involvement was characterized by elevation of warm more than cold detection thresholds. Autonomic dysfunction was less frequent (4). Nerve excitability parameters in both upper and lower limbs provided evidence of membrane depolarization compared with controls, even in those patients without a history of alcohol abuse. No clear correlation was found between neurophysiological indices and scores of hepatic reserve or various blood parameters including ammonia level. Although chronic membrane depolarization may be involved, the degree of depolarization in large fibers was small, and its role in the pathophysiology of neuropathy uncertain.
Karl Ng; Cindy S-Y Lin; Nicholas M F Murray; Andrew K Burroughs; Hugh Bostock
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  35     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-24     Completed Date:  2007-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  730-8     Citation Subset:  IM    
Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.
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MeSH Terms
Alcoholism / complications
Autonomic Pathways / physiopathology
Cell Membrane / physiology
Electrodiagnosis / methods*
Hyperammonemia / blood,  complications
Liver Failure / complications*,  physiopathology
Middle Aged
Nerve Fibers, Myelinated / physiology
Nerve Fibers, Unmyelinated / physiology
Neural Conduction* / physiology
Peripheral Nerves / metabolism,  physiopathology*
Peripheral Nervous System Diseases / diagnosis*,  etiology,  physiopathology*
Reference Values
Sensory Thresholds / physiology
Temperature Sense / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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