Document Detail

Conditions necessary for the formation of serous detachment. Experimental evidence from the cat.
MedLine Citation:
PMID:  8002843     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate experimentally the conditions necessary for the formation of serous detachments. METHODS: Selective injury to the retinal pigment epithelium (RPE) and choriocapillaris was produced in cats using weak laser burns and intense diffuse light, with or without photosensitization with rose bengal. The fundi were analyzed by observation, fluorescein angiography, and histologic examination. RESULTS: Injuring the RPE alone did not cause detachments. Focal injury to the RPE and choriocapillaris caused moderate detachment only when an area surrounding the focal leakage site had been subjected to light damage. Diffuse injury to the RPE and choriocapillaris caused broader detachments. CONCLUSIONS: Three conditions are necessary for serous detachments to form: (1) a source of fluid pressure, (2) a defect in the blood-retinal barrier (entry site), and (3) an area of impaired fluid transport beyond the site of leakage (if fluid is to accumulate over a broader area).
M F Marmor; X Y Yao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  112     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-12     Completed Date:  1994-07-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  830-8     Citation Subset:  AIM; IM    
Department of Ophthalmology, Stanford University School of Medicine, Calif.
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MeSH Terms
Blood-Retinal Barrier / physiology
Choroid / physiology
Intraocular Pressure
Laser Therapy
Pigment Epithelium of Eye / injuries,  physiopathology
Retina / pathology,  physiopathology
Retinal Detachment / etiology*,  pathology,  physiopathology
Rose Bengal
Grant Support
Reg. No./Substance:
11121-48-5/Rose Bengal

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